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Measures of Exposure Using Biological Samples

Vacuum sampler used to collect dust in the fieldThis study will look at the relationship between levels of pollutants in the body and potential routes of exposure. For each study participant, we will have a 24-hour recall of diet, an abbreviated food frequency questionnaire, time activity information, exposure to smoke, and consumer product use, and indoor air pollution sources. We will obtain a first-morning void urine sample corresponding to the 24 hour dietary information and a blood sample to be analyzed for the compounds of interest. We will also collect a sample of dust from their home.

We will be able to assess very different aspects of exposure related behavior by assessing body burdens of different compounds. Specific examples are given below.

  • Intake of fruits and vegetables as well as pesticide use in the home can be evaluated by comparing with body burdens of current use pesticides.

  • Our assessment of temporal changes in exposure to environmental tobacco smoke for non-smokers can be evaluated with the two measures of cotinine.

  • Exposure to BDEs is thought to result from both long term ingestion of high fat foods as well as contact with polyurethane foam and electronics and thus we can evaluate the effectiveness of the food frequency component of our questionnaire and the home assessment component of our questionnaire. Exposures will also be related to levels of this compound in dust in the homes.



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